85-2643-65　Urantide 1mg　257028

特徴

• Urantide acts as a competitice urotensin-II(UT) antagonist, blocking contractions in the thoracic aorta. Selective and competitive urotensin-II (UT) receptor antagonist pK = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acetylcholine-induced relaxation. Behaves as a partial agonist in a calcium mobilization assay (in CHO cells expressing hUT receptors).
• Synonyms:L-α-Aspartyl-3-mercapto-L-valyl-L-phenylalanyl-D-tryptophyl-L-ornithyl-L-tyrosyl-L-cysteinyl-L-valine Cyclic (2→7)-Disulfide
• Molecular Formula:C₅₁H₆₆N₁₀O₁₂S₂•x(C₂HO₂F₃)
• Molecular Weight:1075.26 anhy
• Purity:≥95%
• Appearance:White to off-white solid
• Solubility:Ethanol (Very Slightly), Methanol (Slightly), Water (Slightly)
• Melting Point:> 175°C (dec.)
• Method for Determining Identity:Proton NMR Spectroscopic, F NMR Spectroscopic and Mass Spectrometric Analysis
• Elemental Analysis:As Reported
• Specific Rotation (c=0.1, Methanol):As Reported
• Water Content (KF):As Reported
• Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months after receipt. Hygroscopic, under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.