85-2620-25　J 104129 Fumarate 10mg　255545

特徴

• Potent M3 muscarinic receptor antagonist that displays ~ 120-fold selectivity over M2 receptors (Ki values are 4.2, 19 and 490nM for human M3, M1 and M2 receptors respectively). Exhibits >250-fold bronchial selectivity; inhibits ACh-induced bronchoconstriction but not ACh-induced bradycardia (KB values are 3.3 and 170 nM for rat trachea M3 and rat right atria M2 receptors respectively).
• Synonyms:(αR)-α-Cyclopentyl-α-hydroxy-N-[1-(4-methyl-3-pentenyl)-4-piperidinyl]benzeneacetamide Fumarate; (αR)-α-Cyclopentyl-α-hydroxy-N-[1-(4-methyl-3-pentenyl)-4-piperidinyl]benzeneacetamide (2E)-2-Butenedioate (1:1) (salt) (9CI)
• Molecular Formula:C₂₄H₃₆N₂O₂ • (C₄H₄O₄)
• Molecular Weight:500.63
• Purity:≥99% (HPLC)
• Appearance:White solid
• Solubility:DMSO to 100mM, ethanol to 50mM
• Method for Determining Identity:Proton NMR Spectroscopic and Mass Spectrometric analysis
• TLC Conditions:Rf=0.52 (Dichloromethane: Methanol: Ammonia soln [9:1:0.05])
• Microanalysis:Calculated: %C: 67.18, %H: 8.05, %N: 5.60
• Optical Rotation:[a] = -7.7 (Concentration=1, Solvent=Methanol)
• Storage and Stability:Powder is stable for 6 months after receipt at 4°C.