85-2618-89　HMR 1556 10mg　CAS No:223749-46-0　255458

特徴

• Potent and selective Iks channel blocker (IC50 values are 10.5 and 34nM in canine and guinea pig ventricular myocytes respectively). Selectively inhibits IKs currents over IKr, IKI, Ito and L-type Ca2+ channel currents. Also has little or no effect on Kv11.1 Kv1.5, Kv1.3, Kir2.1 and HCN2 channel currents. Potentiates E-4031-induced arrhythmias in vivo.
• Appearance:White solid
• Purity:≥99%
• Solubility:Soluble to 10mM in DMSO, 20mM in ethanol
• TLC:Rf = 0.06 (30% EtOAc in petroleum spirits
• HPLC:≥99.4%
• Chiral HPLC:100%%
• 1H NMR:Consistent with structure
• Mass Spectrum:Consistent with structure
• Microanalysis:Carbon Hydrogen Nitrogen Theoretical 49.63 5.88 3.4Found 49.81 5.98 3.45
• Storage:Store at RT
• Molecular Weight:411.44
• Formula:C17H24F3NO5S