85-2617-49　Gedunin 2.5mg　CAS No:2753-30-2　255370

特徴

• Gedunin is a naturally occurring Hsp90 inhibitor. In vitro, Gedunin induces Hsp90-dependent client protein degradation and displays antiproliferative activity (IC50 values are 3.22, 8.84 and 16.8uM in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Gedunin exhibits antimalarial activity against P. falciparum (IC50 values are 0.14 and 3.1uM in parasite development and [3H]-hypoxanthine uptake assays respectively).
• Synonyms:(1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a-decahydro-4b,7,7,10a,12a-pentamethyloxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione; Gedunine; NSC 113497; (5α,7α,13α,14β,15β,17aα)-7-(Acetyloxy)-14,15:21,23-diepoxy-4,4,8-trimethyl-D-homo-24-nor-17-oxachola-1,20,22-triene-3,16-dione
• Molecular Formula:C₂₈H₃₄O₇
• Molecular Weight:482.57
• Appearance:White to off-white solid
• Purity:≥97% (HPLC)
• Method for Determining Identity:Proton NMR and MS
• Optical Rotation:[a]D = +69.5 (c=1; Solvent: Methanol)
• Elemental Analysis:%C: 68.61, %H: 7.51
• Melting Point:>199°C (dec.)
• Solubility:Chloroform (Slightly)
• Storage and Stability:Store at -20°C under inert atmosphere. Hygroscopic, under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.