85-2615-92　Erastin 1mg　CAS No:571203-78-6　255262

特徴

• Erastin is a selective antitumor agent that displays greater lethality in human tumor cells harboring mutations in the oncogenes HRAS, KRAS or BRAF. It binds to mitochondrial volatage-dependent anion channels (VDAC) proteins, more specifically on VDAC2 and alters its gating. Erastin rapidly induces an oxidative, non-apoptotic cell death in several human tumors harboring activating mutations in the RAS-RAF-MEK signaling.
• Synonyms:2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone
• Molecular Formula:C₃₀H₃₁ClN₄O₄
• Molecular Weight:547.04
• Appearance:Supplied as a white solid
• Purity:≥98%
• Melting Point:173-177ºC
• Solubility:Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly)
• Method for Determing Identity:Proton NMR (DMSO-d6, CDCl3) and Mass Spectrometric Analysis
• TLC Conditions:SiO2; Ethyl Acetate: Hexane=9:1; Visualized with UV and AMCS; Single Spot, Rf=0.55
• Elemental Analysis:Calculated: %C: 65.87; %H: 5.71; %N: 10.24
• Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at 4ºC. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
• Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.