Potent inhibitor of protein kinase D (PKD); inhibits all PKD isoforms (IC50 values are 1, 2 and 2.5nM for PKD1, PKD3 and PKD2 respectively). Exhibits selectivity for PKD against a panel of >90 protein kinases, including PKC-alpha, MEK, ERK, c-Raf and c- Src. Reduces proliferation and cell viability of pancreatic cancer cells expressing moderate levels of endogenous PKD1/2. Orally bioavailable.
Appearance:Yellow solid
Purity:≥98%
Solubility:Soluble in water to 20mM and soluble in DMSO to 10mM
Method for Determining Identity:Proton NMR and MS
Elemental Analysis:Calculated: 50.35% C; 6.1% H; 19.57% NFound: As reported
Storage and Stability:Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
