Potent and selective P2X receptor antagonist. Blocks P2X -mediated currents in Chinese hamster ovary cells (IC = 0.50uM). Exhibits no significant antagonist effects at other P2X receptors. Reduces long-term potentiation (LTP) in rat hippocampal slices.
Chemical Name:5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one
Method for Determining Identity:Proton NMR and Mass Spec
TLC:Rf = 0.58 (Chloroform:Methanol [9:1])
Molecular Formula:C₁₇H₁₁BrN₂O₂
Solubility:Soluble to 100mM in DMSO
Molecular Weight:355.19
Purity:≥99% (HPLC)
Appearance:Off-white solid
Storage and Stability:Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
