Panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions. Inhibits P2X7-mediated dye uptake, ATP-mediated IL-1β release and caspase-1 activation without altering membrane current in macrophages in vitro. Also blocks activation of NMDA receptor secondary currents (I2nd) by >70%.
Molecular Weight:1242.37
Molecular Formula:C58H79N15O16
Sequence:WRQAAFVDSY
Solubility:Soluble to 1mg/ml in water
Method for Determining Identity:Mass Spectrometric Analysis
Net Peptide Content:91%
Counter Ion:TFA
Appearance:Supplied as a white lyophilized solid.
Purity:~96% (HPLC)
Storage and Stability:Lyophilized and reconstituted products may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
