85-2589-13　［取扱停止］Tyloxapol, USP 1g　CAS No:25301-02-4　242554

特徴

• Tyloxapol is a nonionic liquid polymer of the alkyl aryl polyether alcohol type. It is used as a surfactant to aid liquefaction and removal of mucopurulent[citation needed] (containing mucus and pus) bronchopulmonary secretions,[1][2] administered by inhalation through a nebulizer[3] or with a stream of oxygen. With intraperitoneal injection, tyloxapol also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins. This mechanism is used to induce experimental hyperlipidemia in animals.[4] Tyloxapol is the main active ingredient of the medical device Tacholiquin®. Tacholiquin® is an expectorant designated for inhalation and instillation reaching the upper and lower airways.
• Synonyms:p-(1,1,3,3-Tetramethylbutyl)Phenol Polymer with Ethylene Oxide and Formaldehyde; Ethylene Oxide Polymer with Formaldehyde and p-(1,1,3,3-Tetramethylbutyl)phenol; Oxirane Polymer with Formaldehyde and 4-(1,1,3,3-tetramethylbutyl)phenol; Ethylene oxide-formaldehyde-4-(1,1,3,3-tetramethylbutyl)phenol copolymer; Ethylene oxide-formaldehyde-p-octylphenol Copolymer; NSC 90255; Superinone; Triton A 20; Triton WR 1339; Tyloxapol; p-Isooctylpolyoxyethylenephenol Formaldehyde Polymer;
• Molecular Formula:(C17H30O4)n
• Molecular Weight:As reported
• Appearance:Yellow to brown viscous liquid
• Purity:As reported
• Identity (UV):Conforms to structure. Exhibits maximum and minimum at the same wavelengths as RS
• Identity (IR):Conforms to structure
• Melting Point:As reported
• Cloud Point:92-97°C
• Free Phenol:No cloudiness or precipitation immediately
• Limit of Formaldehyde:≤0.0075%
• Ethylene Oxide:≤0.001%
• Toluene:≤0.01% (Action Limit)≤0.04% (0.04%)
• Limit of Anionic Detergents:≤0.075% as sodium lauryl sulfate
• Absence of cationic detergents:No blue color in the organic solvent lay
• Water (Karl Fisher):≤1%
• pH:5-7
• Residue On Ignition:≤1%
• Refractive Index (n25D):1.495 - 1.501
• Solubility:Slowly but freely miscible with water
• Soluble in glacial Acetic acid, Toluene, and Chloroform.
• Storage:4°C