85-2423-83　Erythromycin 5g　CAS No:114-07-8　237532

特徴

• Erythromycin displays bacteriostatic activity or inhibits growth of bacteria, especially at higher concentrations,[25] but the mechanism is not fully understood. By binding to the 50s subunit of the bacterial rRNA complex, protein synthesis and subsequent structure and function processes critical for life or replication are inhibited.[25] Erythromycin interferes with aminoacyl translocation, preventing the transfer of the tRNA bound at the A site of the rRNA complex to the P site of the rRNA complex. Without this translocation, the A site remains occupied, thus the addition of an incoming tRNA and its attached amino acid to the nascent polypeptide chain is inhibited. This interferes with the production of functionally useful proteins, which is the basis of this antimicrobial action.
• Synonyms:E-Base; E-Mycin; Erytromycin A; Aknemycin; Aknin; emgel; Ery-Derm; Erymax; Ery-Tab; Erythromid; ERYC
• Molecular Formula:C₃₇H₆₇NO₁₃
• Molecular Weight:733.98
• Purity:85.0-100.5% (Dry basis)
• Appearance:White or almost white crystalline powder
• Water (Karl Fisher):≤10%
• Optical Rotation:-71° to -78°
• Residual Solvents:≤0.05% (Acetone)≤0.05% (n-Butyl acetate)
• Related Substances:Erythromycin A enol ether: ≤3%Erythromycin B: ≤12%Erythromycin C: ≤5%Any individual impurity: ≤3%
• Residue On Ignition:≤0.2%
• Limit of Thiocynate:≤0.3%
• Storage and Stability:Powder is stable for 6 months after receipt at 4°C.
• Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
• Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.