85-2398-71　Calcium D-Saccharate Tetrahydrate, 98.5-102.0% USP 250g　CAS No:5793-89-5　236779

特徴

• Calcium D-glucarate is the calcium salt form of D-glucaric acid.1 D-Glucaric acid is an end product of D-glucuronic acid metabolism in mammals that has also been found in fruits and vegetables and has anticancer activity.2 It is produced by the oxidation of D-glucuronic acid and is a precursor in the biosynthesis of the β-glucuronidase inhibitor D-glucaro-1,4-lactone (D-saccharic acid 1,4-lactone) in vivo.1 Dietary administration of calcium D-glucarate (10% w/w) reduces tumor growth in a rat model of mammary tumorigenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA).3 Urinary D-glucaric acid levels have been used as a marker for xenobiotic-induced phase II metabolism in patients with rheumatoid arthritis or individuals exposed to environmental toxicants.4,5
• Synonyms:Calcium D-Saccharate; D-Glucaric Acid Calcium Salt; D-Saccharic Acid Calcium Salt
• Molecular Formula:C6H8O8•Ca [4H2O]
• Molecular Weight:320.26
• Appearance:White crystalline powder
• Purity:98.5-102.0% (Titration)
• Infrared Spectrum:Conforms to structure
• Optical Rotation:[a]D20 = +18.5 to 22.5º (C=1 in 5N HCl)
• Heavy Metals:≤0.002%
• Chloride:≤0.07%
• Sulfate:≤0.12%
• Calcium:Positive test
• Reducing Substances:Sucrose & Reducing sugar: Should be absent
• Solubility:Soluble in calcium gluconate solutionMethanol: slightly solublePBS (pH 7.2): slightly soluble
• Storage and Stability:May be stored at RT.