85-2090-71　Epoxomicin 250ug　CAS No:134381-21-8　226810

特徴

• Antibiotic. Potent anticancer compound. Cell permeable, potent, selective and irreversible 20S proteasome inhibitor. Predominantly inhibits the chymotrypsin-like (CTRL) activity of the proteasome. Exhibits lower level inhibition of proteasome trypsin-like and caspase-like activitives (100 and 1,000-fold slower rates respectively). Anti-inflammatory. Antimicrobial and antimalarial. Anti-parasitic. Stimulates bone formation by inhibiting osteoblast proteasome activity. Induces Parkinson's-like symptoms in rats. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems. Blockade of UPS by Epoxomicin activates autophagy.
• Alternate Names:N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-L-threoninamide, BU 4061T
• Source:Synthetic
• Molecular Formula:C₂₈H₅₀N₄O₇
• Molecular Weight:554.7
• Solubility:Soluble in DMSO. Insoluble in water.
• Purity:≥97% (NMR)
• Appearance:Supplied as a white to off-white solid.
• Storage and Stability:Stable for 1 year after receipt when stored at -20°C. Keep cool and dry. Protect from light and moisture.
• Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
• Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.