85-2090-12　WWTR1, Recombinant, Human, aa1-400, His-Tag (WW Domain Containing Transcription Regulator 1, Transcriptional Coactivator with PDZ-binding Motif, TAZ) 500ug　218678

特徴

• WWTR1 is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.
• Source:Recombinant corresponding to aa1-400 from human WWTR1 protein, fused to His-tag at N-terminus, expressed in E.coli.
• Molecular Weight:~46.5kD (423aa)
• Applications:Suitable for use in SDS-PAGE. Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.