85-2088-29　SIRPA, Recombinant, Human, aa27-373, His-Tag (Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1, Signal Regulatory Protein Alpha, BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP) 100ug　218563

特徴

• SIRPA is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. It was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein.
• Source:Recombinant protein corresponding to aa27-373 from human SIRPA, fused to His-tag at N-terminus, expressed in E.coli.
• Molecular Weight:~40.4kD (370aa)
• Applications:Suitable for use in SDS-PAGE. Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.