85-2087-97　［取扱停止］SELPLG, Recombinant, Human, aa42-121, His-Tag (P-Selectin Glycoprotein Ligand 1 Isoform 2 Precursor, CD162) 20ug　218545

特徴

• SELPLG is a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.
• Source:Recombinant corresponding to aa42-121 from human SELPLG protein, fused to His-tag at N-terminus, expressed in E.coli.
• Molecular Weight:~10.9kD (103aa), confirmed by MALDI-TOF (Molecular size on SDS-PAGE will appear higher)
• Applications:Suitable for use in SDS-PAGE. Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.