85-2085-29　NABP1, Recombinant, Human, aa1-204, His-Tag (Nucleic Acid Binding Protein 1) 100ug　218380

特徴

• Nucleic acid binding protein 1, also known as NABP1, is a component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, the protein acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. This protein is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
• Source:Recombinant protein corresponding to aa1-204 from human NABP1, fused to His-tag at N-terminus, expressed in E.coli.
• Molecular Weight:~24.8kD (227aa), confirmed by MALDI-TOF
• Applications:Suitable for use in SDS-PAGE. Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.