85-2083-16　IDO1, Recombinant, Human, aa1-403, His-Tag (Indoleamine 2 3-Dioxygenase 1, Indoleamine 2,3-Dioxygenase 1, IDO, IDO-1, INDO) 100ug　218244

特徴

• IDO1 is an indoleamine 2,3-dioxygenase - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, and serotonin. It is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.
• Source:Recombinant protein corresponding to aa1-403 from human IDO1, fused to His-tag at N-terminus, expressed in E.coli.
• Molecular Weight:~47.7kD (426aa), confirmed by MALDI-TOF
• Applications:Suitable for use in SDS-PAGE. Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.