A potent antagonist highly selective for GluK1 (Kb = 10nM), GluK3 (IC50 = 23nM), and GluK1/K5 (Kb = 8nM) subtype kainate receptors. Does not interact with GluK2 and GluK2/K5 receptors. Low affinity to AMPA receptors (Kd = 83uM). Does not interact with mGluR1 ornMDA receptors at concentration less than 10uM. Often used in studying neuronal excitability and synaptic plasticity.
Formula:C14H15N3O6S
Solubility:DMSO
Primary Target:GluK1
Primary Target Ki:10nM
Secondary Target:Gluk3
Storage and Stability:May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
