85-2077-05　Syk Inhibitor V ((S)-2-(2-((3,5-dimethylphenyl)amino)pyrimidin-4-yl)-N-(1-hydroxypropan-2-yl)-4-methylthiazole-5-carboxamide, Spleen Tyrosine Kinase Inhibitor) 2mg　217819

特徴

• A cell-permeable, 4-thiazolyl-2-phenylaminopyrimidine compound that acts as a potent, reversible, and ATP-competitive inhibitor of spleen tyrosine kinase (Syk) (Ki=9nM). Exhibits excellent selectivity over Cdk2 (Ki=3.33uM), ROCK (Ki=2.3uM), Src (Ki=3.33uM), and ZAP70 (Ki=240nM). Shown to inhibit mast cell degranulation (IC50=70nM) that is commonly observed in asthma and other allergic diseases.
• Synonyms: (S)-2-(2-((3,5-dimethylphenyl)amino)pyrimidin-4-yl)-N-(1-hydroxypropan-2-yl)-4-methylthiazole-5-carboxamide, Spleen Tyrosine Kinase Inhibitor
• Molecular Formula:C₂₀H₂₃N₅O₂S
• Molecular Weight:397.5
• Solubility:DMSO (50mg/ml, pale yellow solution)
• Storage and Stability:Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

仕様

• Size：2mg
• Grade：Highly Purified
• Purity：≥99% (HPLC)
• Form：Supplied as a yellow solid.
• Molecular Formula：C₂₀H₂₃N₅O₂S
• Molecular Weight Non Ab：397.5
• EU Commodity Code：38220090
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