85-2076-92　Sphingosine Kinase 1 Inhibitor, SKI-178 (N'-(1E)-1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide, Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide) 10mg　217804

特徴

• A cell-permeable pyrazolocarbohydrazide compound that acts as a potent, reversible, sphingosine competitive and ATP-non-competitive inhibitor of sphingosine kinase 1 (SphK1) activity with excellent selectivity over SphK2 (Ki = 1.33 and >> 25uM, respectively). Shown to suppress sphingosine-1-phosphate (S1P) production in A549 cells and efficiently induce apoptosis in several tumor cells (IC50 in the range of 0.1-1.8uM).
• Synonyms:Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide, Nʹ-(1E)-1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide
• Molecular Formula:C₂₁H₂₂N₄O₄
• Solubility:DMSO
• Molar Mass:394.4
• Storage and Stability:Store at 4°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

仕様

• Size：10mg
• Grade：Highly Purified
• Purity：≥92% (HPLC)
• Form：Supplied as an off-white powder.
• Molecular Formula：C₂₁H₂₂N₄O₄
• Molecular Weight Non Ab：394.4
• EU Commodity Code：38220090
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