85-2076-86　Smoothened Agonist, SAG (N-Methyl-N’-(3-pyridinylbenzyl)-N’-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane, SAG1.3 ) 1mg　CAS No:364590-63-6　217797

特徴

• A cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (=59nM). Shown to induce Smo internalization. Shown to induce Hedgehog pathway activation (EC50= ∼3nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations.
• Synonyms: N-Methyl-Nʹ-(3-pyridinylbenzyl)-Nʹ-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane, SAG1.3
• Molecular Formula:C₂₈H₂₈ClN₃OS • 2HCl • 2H₂O
• Molecular Weight:599
• Purity:≥98% (HPLC)
• Appearance:White to yellow solid
• Solubility:DMSO (10mg/ml) or H2O
• NMR:Conforms to structure
• Mass Spectrophotometry:Conforms to structure
• Elemental Analysis:As Reported
• Storage and Stability:May be stored at 4°C. Stable for 6 months after receipt. Reconstitute with DMSO or H2O. Aliquot and store at -20°C.