85-2076-84　［受注停止］SKP2 E3 Ligase Inhibitor II, SMIP004 (CRL1SKP2 Inhibitor II, p21/Cip1/CKI/Waf1 Activator II, N-(4-Butyl-2-methylphenyl)acetamide, p27/Kip1 Activator II, S-phase Kinase-associated Protein 2 Inhibitor II, SCFSKP2 Inhibitor II, Small Molecule Inhibitor of p27 Depletion 004) 25mg　CAS No:143360-00-3　217795

特徴

• A cell-permeable phenylacetamide compound that is shown to upregulate p21Cip1/Waf1 and/or p27Kip1 in prostate cancer LNCaP, PC3, DU145, but not HeLa, cultures (40uM for 24h) with a concomitant downregulation of the F-box E3 ubiquitin ligase Skp2 and a delayed G1-to-S cell cycle transition, displaying no apparent effect toward cell cycle progression or p21 and p27 levels in non-cancer human fibroblast IMR90. SMIP004 antiproliferative activity against LNCaP, PC3, DU145 soft agar colony formation is mainly cytostatic with cytotoxicity observed only in LNCaP cultures at high concentrations (IC50 = 40uM in 72h), but not PC3 or DU145 even at concentrations as high as 80uM and for up to 96h.
• Synonyms:p27/Kip1 Activator II, S-phase Kinase-associated Protein 2 Inhibitor II, SCFSKP2 Inhibitor II, Small Molecule Inhibitor of p27 Depletion 004, CRL1SKP2 Inhibitor II, p21/Cip1/CKI/Waf1 Activator II, N-(4-Butyl-2-methylphenyl)acetamide
• Molecular Formula:C₁₃H₁₉NO
• Solubility:DMSO
• Molar Mass:205.30
• Purity:≥99% (HPLC)
• Form:Supplied as a white solid.
• Storage and Stability:May be stored at 4°C for short-term only. Long-term storage is recommended at -20°C. Stable for 1 year after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.