85-2076-79　SHIP2 Inhibitor, AS1938909 (3-(2,4-Dichlorobenzyl)oxy]-N-(2,6-difluorobenzyl)thiophene-2-carboxamide, SH2 Domain-containing Inositol 5’-phosphatase 2 (SHIP2) Inhibitor) 10mg　217790

特徴

• A cell-permeable thiophenecarboxamide compound that is shown to increase glucose metabolism and activate intracellular insulin signaling. Acts as a potent, competitive and reversible inhibitor of SHIP2 activity (Ki=0.44uM for hSHIP2) with moderate to excellent selectivity over SHIP1 and other related phosphatases (IC50=0.18, 0.57, 21, >50, >50 and >50uM for mSHIP2, hSHIP2, hSHIP1, hPTEN, h-synaptojanin and h-myotubularin, respectively). Elevates insulin-induced pAkt-Ser473 levels and enhances glucose transporter GLUT1 mRNA expression in L6 myotubes. SHIP1 Inhibitor, 3AC is also available.
• Formula:C₁₉H₁₃Cl₂F₂NO₂S
• Solubility:DMSO
• Molecular Weight:371.9
• Storage and Stability:May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

仕様

• Size：10mg
• Grade：Highly Purified
• Purity：≥95% (HPLC)
• Form：Supplied as an off-white solid.
• Molecular Formula：C₁₉H₁₃Cl₂F₂NO₂S
• Molecular Weight Non Ab：371.9
• EU Commodity Code：38220090
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