85-2076-74　gamma-Secretase Inhibitor XXV, FT-9 (2-[3-(3,5-dichlorophenoxy)phenyl]propanoic Acid) 10mg　217786

特徴

• FT-9, a cell-permeable NSAID-like compound, is a partially selective gamma-Secretase Inhibitor in both microsomes and whole cells. Displays dose-dependent inhibition of the gamma-secretase cleavage of beta-Amyloid Precursor Protein (APP) and APLP2 with IC50 values against APP ICD (intracellular domain) and APLP2 ICD of ˜260uM, but there is a less potent effect on gamma-secretase processing of APLP1. The concentration of FT-9 required to cause a 2-fold increase in APP CTFs, 3.4 +/- 0.4uM, is significantly lower than that for APLP1 (25.7 +/- 8.9uM) (P = 0.001). For comparison, the concentration of another gamma-Secretase inhibitor compound E needed for a 2-fold increase in the magnitude of the CTF band signal is not significantly different, being 0.27nM for APP versus 0.24nM for APLP1. This is the first example that a GSI can preferentially target APP processing while sparing other gamma-substrates.
• Synonyms:2-[3-(3,5-dichlorophenoxy)phenyl]propanoic acid
• Molecular Formula:C₁₅H₁₂Cl₂O₃
• Solubility:DMSO
• Molar Mass:311.2
• Storage and Stability:May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.