85-2076-67　SB 399885 Hydrochloride (5-HT6 Receptor Antagonist, SB 399885) 25mg　CAS No:402713-80-8　217780

特徴

• A high affinity 5-HT6 Receptor antagonist (pKi = 9.0). Good solubility (to 100mM in water or DMSO), oral availability, and penetrant to blood brain barrier. Over 200-fold selective for 5-HT6 receptors vs all receptors, ion channels and enzymes tested in Hirst et al. 2006 publication. Shows nootropic, antidepressant and axiolytic effects comparable to well-described drugs such as diazepam, and therefore has been proposed as novel treatment for schizoprenia and Alzheimer’s disease.
• Solubility:DMSO or H2O
• Primary Target:5-HT6
• Primary Target Ki:1nM
• Storage and Stability:May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

仕様

• Size：25mg
• Grade：Highly Purified
• Purity：~99% (HPLC)
• Form：Supplied as a white solid.
• Molecular Formula：C₁₈H₂₁Cl₂N₃O₄S • (HCl)
• EU Commodity Code：38220090
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• CAS No ：402713-80-8

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