A highly potent and selective non-alkaloid positive allosteric modulator of Kappa-opioid receptors (Ki = 4.3nM and 16nM for native and cloned kappa-opioid receptors, respectively). Also acts as a D2DR partial agonist (Ki = 5-10nM). Used in studies of addition.
Formula:C₂₃H₂₈O₈
Solubility:DMSO (50mM) or Ethanol (10mM)
Primary Target:k opioid receptor
Primary Target Ki:4.3nM
Storage and Stability:Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
