A potent and selective beta-2-adrenoceptor agonist (EC50 = 5.3nM) that displays bronchodilator actions. Unlike other beta-2- adrenoceptor agonists, Salmeterol binds to exo-site domain of beta-2-AR receptors, producing a slow onset of action and prolonged activation. Clinically used for the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at 4°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.