Dopamine D2 receptor antagonist with good aqueous solubility. S-sulpiride (200nM) was used to confirm that dopamine currents were mediated through the D2 receptor in whole animal rat brain preps. IC50 of 0.01012uM Antagonist activity at human dopamine D2 receptor expressed in CHOp cells assessed as inhibition of quinopirole-induced mitogenisis.
Storage and Stability:May be stored at 4°C. Following reconstitution, aliquot and freeze at -20°C. Stable for 1 year after receipt. Protect from light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.