A non-selective antagonist for group I/II mGlu receptors (minimal values of IC50 reported = 40 and 15uM for mGlu1 and mGlu2, respectively). Often used as an agent to differentiate excitatory neurotransmissions mediated by glutamate from other neurotransmitters (i.e. dopamine, acetylcholine, and GABA in early brain development). A common component of cocktails for blocking glutamate transmission in brain slice preparation.
Synonyms:(S)-α-Methyl-4-carboxyphenylglycine, Group I/II mGlu Antagonist, (S)-MCPG
Molecular Formula:C₁₀H₁₁NO₄
Solubility:H2O or DMSO
Primary Target:Grup I and II mGlu receptors
Primary Target IC50:40 and 15 →M for mGlu1 and mGlu2, respectively.
Purity:≥99% (HPLC)
Form:Supplied as a white solid.
Storage and Stability:May be stored at 4°C for short-term only. Long-term storage is recommended at -20°C. Stable for 1 year after receipt. Protect from light when in solution. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
