85-2076-34　RGS Proteins Inhibitor II, CCG-50014 (4-(4-Fluorobenzyl)-2-p-tolyl-1,2,4-thiadiazolidine-3,5-dione) 10mg　217741

特徴

• A cell-permeable thiadiazolidinedione compound that acts as a direct, potent, selective and cysteine-reactive irreversible inhibitor of RGS4 over other RGS proteins (IC50=0.03, 0.12, 3.5, 11, >200 and >200uM against RGS4, RGS19, RGS16, RGS8, RGS7 and RGS4Cys- using FCPIA assay, respectively). Shown to block RGS4-Ga0 interaction and repress Ga0-dependent membrane localization of RGS4 in HEK-293T cells with no effect on the intrinsic rate of GTP hydrolysis by Ga0. Suggested to interact with Cys107-RGS8 allosteric regulatory site and display minimal affinity towards papain (IC50>100uM).
• Synonyms:4-(4-Fluorobenzyl)-2-p-tolyl-1,2,4-thiadiazolidine-3,5-dione
• Formula:C₁₆H₁₃FN₂O₂S
• Molecular Weight:316.4
• Solubility:DMSO (50mg/ml)
• Appearance:Supplied as a white solid.
• Purity:≥98% (HPLC)
• Storage and Stability:Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.