85-2076-29　Rad6 Inhibitor (4-Amino-6-(phenylamino)-[1,3,5]triazin-2-yl)methyl-4-nitrobenzoate, (4-Amino-6-(phenylamino)-1,3,5-triazin-2-yl)methyl 4-nitrobenzoate, TZ9, TZ-9, TZ 9, HHR6 Inhibitor) 10mg　CAS No:002789-86-7　217735

特徴

• A cell-permeable triazine compound that directly targets human E2 Ubiquitin-conjugating enzyme Rad6B/HHR6B catalytic site via noncovalent interactions and effectively inhibits Rad6B-Ub thioester bond formation as well as subsequent substrate ubiquitination without affecting UbcH5B/UBE2D2-catalyzed BCA2 ubiquitination. Shown to inhibit the proliferation of high Rad6B-expressing MDA-MB-231 (IC50 = 6uM in 72h), but not the low Rad6B-expressing, non-transformed MCF10A, via G2/M arrest and apoptosis induction. Two known cellular Rad6 substrates, beta-catenin and PCNA, are reported to be downregulated following 24h inhibitor treatment in MDA-MB-231 cultures (0.5 to 5uM).
• Synonyms: 4-Amino-6-(phenylamino)-[1,3,5]triazin-2-yl)methyl-4-nitrobenzoate, (4-Amino-6-(phenylamino)-1,3,5-triazin-2-yl)methyl 4-nitrobenzoate, HHR6 Inhibitor, TZ9, TZ-9, TZ 9
• Molecular Formula:C₁₇H₁₄N₆O₄
• Primary Target:Rad6B/HHR6B
• Solubility:DMSO
• Storage and Stability:Store at 4°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.