85-2076-26　Rac Inhibitor III, EHop-016 10mg　CAS No:1380432-32-5　217731

特徴

• A cell-permeable NSC23766 analog that is more selective against Rac interaction with Vav2 (by 45% blockage at 4uM) than Tiam (35% blockage at 50uM) and ~100-times more potent than NSC23766 in suppressing Rac1-GTP level in MDA-MB-435 (IC50=1.1 vs. 95uM, respectively) cultures. Effectively inhibits PAK Thr423 phosphorylation (IC50 <2uM), while reducing Cdc42-GTP level only at higher concentrations (by 18% at 5uM), in MDA-MB-435 cultures.
• Rac Inhibitor III, EHop-016, CAS 1380432-32-5, is a cell-permeable analog of NSC23766. It is ~100-fold more potent than NSC23766 in suppressing Rac1-GTP level in MDA-MB-435 cells.
• Synonyms:N⁴-(9-Ethyl-9H-carbazol-3-yl)-N²-(3-morpholin-4-yl-propyl)-pyrimidine-2,4-diamine
• Molecular Formula:C₂₅H₃₀N₆O
• Solubility:DMSO
• Molecular Weight:430.6
• Purity:≥96% (HPLC)
• Appearance:Pale yellow powder
• Storage and Stability:May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.