85-2075-89　Pre-mRNA Splicing Inhibitor, Isoginkgetin 10mg　CAS No:548-19-6　217696

特徴

• A cell-permeable, naturally isolated Ginkgo biloba biflavanoid that acts as a general pre-mRNA splicing inhibitor (ICmax=50uM in splicing assays using HeLa nuclear extract) by blocking the spliceosome-meidated splicing process at the prespliceosome/A complex stage. Isoginkgetin treatment is shown to result in growth arrest in HEK293-derived cultures in a reversible manner without affecting cell viability (33uM for 24h).
• 217696 is a cell-permeable inhibitor of pre-mRNA splicing. Blocks spliceosome-mediated splicing process at the pre-spliceosome/A complex stage.
• Synonyms: 8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
• Molecular Formula:C₃₂H₂₂O₁₀
• Molecular Weight:566.5
• Solubility:DMSO (100mg/ml)
• Appearance:Supplied as a yellow solid.
• Purity:≥98% (HPLC)
• Storage and Stability:Store at -20°C under inert atmosphere. Protect from light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.