A cell-permeable non-thiazolidinediones derivative that binds tightly to peroxisome proliferator-activated gamma (PPAR-g) receptor (Ki=29nM; IC50=80nM), but does not exhibit any transcriptional agonism. Unlike TZD compounds, it does not induce weight gain or diminish hematocrit. Shown to effectively block CDK-5-mediated phosphorylation of Ser273 of PPAR-gamma in adipose tissue. Supresses hepatic glucose production, reduces plasma free fatty acid levels, and improves insulin sensitivity of adipose tissue.
Molecular Formula:C₃₃H₂₉N₃O₅
Molecular Weight:547.6
Solubility:DMSO (50mg/ml)
Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
