85-2075-67 PKR Inhibitor III, 7DG (Double-stranded RNA-activated Protein Kinase Inhibitor III, EIF2AK2 Inhibitor III, 7-Desacetoxy-6,7-dehydrogedunin, Double-stranded RNA-dependent Protein Kinase Inhibitor III) 5mg 217675
85-2075-67 PKR Inhibitor III, 7DG (Double-stranded RNA-activated Protein Kinase Inhibitor III, EIF2AK2 Inhibitor III, 7-Desacetoxy-6,7-dehydrogedunin, Double-stranded RNA-dependent Protein Kinase Inhibitor III) 5mg CAS No:26927-01-5 217675
A cell-permeable gedunin analog that directly targets PKR via reversible interaction inhibits PKR-mediated cellular events by disrupting PKR signaling complexes assembly, such as IkK complex and inflammasome/pyroptosome, resulting in effective blockage of LPS-induced IkBbeta degradaion (20uM) and protection against anthrax toxin LT-induced caspase-1 activation as well as subsequent pyroptosis (10uM) in murine macrophage J774 cultures. PKR is also known to mediate LT-induced apoptosis via its kinase activity in LPS-primed Macrophages derived from C57BL/6 with a resistent NLRP1 allele, inhibitable by C16, but not by 7DG, while LT-induced pyroptosis in J774 cultures is insensitive to C16 treatment.
Synonyms:7-Desacetoxy-6,7-dehydrogedunin, Double-stranded RNA-dependent Protein Kinase Inhibitor III, Double-stranded RNA-activated Protein Kinase Inhibitor III, EIF2AK2 Inhibitor III
Molecular Formula:C₂₆H₃₀O₅
Solubility:DMSO
Primary Target:PKR
Purity:≥95% (HPLC)
Appearance:Supplied as a pale yellow solid.
Storage and Stability:Store at 4°C under inert gas. Caution: Light-sensitive. Following reconstitution, aliquot and freeze at -70°C. Stock solutions are stable for 6 months at -70°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
