A potent positive allosteric modulator selective for mGlu4 receptors (EC50 = 3uM). Also, a less potent agonist of mGlu6 receptors (EC50 = 15uM). Biologically active admitted systematically. Often used in assessing the functional roles of mGlu4 receptors or group III mGlu receptors in a variety of research areas, such as epileptic seizures, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson's disease.
Formula:C17H14N2O3
Solubility:DMSO
Primary Target:mGlu4 receptors
Storage and Stability:Store at 4°C. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.