A cell-permeable and blood-brain barrier-permeant aminosalicylic acid compound that selectively disrupts nNOS and PSD-95 interaction uponnMDAR activation both in primary murine cortical neurons (0.8- and 2.8-fold increase from basal level with or without 30min 10uM ZL006 pretreatment) in vitro and in mice (0.4- and 1.9-fold increase from basal level with or without inhibitor pretreatment 15min before ischemia; 1.5mg/kg i.v.) in vivo without affecting nNOS activity or non-nNOS-mediated nMDAR EPSCs (excitatory postsynaptic currents). Effectively reduce ischemia-caused brain tissue damage in both mice and rats when applied 1h after blood reperfusion following ishemia (60% and 50% reduction of infarction, respectively; 1.5mg/kg i.v.).
Formula:C₁₄H₁₁Cl₂NO₄
Molecular Weight:328.2
Solubility:DMSO (50mg/ml)
Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
