85-2074-91　［取扱停止］NMDA Receptor NR2BCT(1292-1304)-TAT (Tat-NR2BCT, H-KKNRNKLRRQHSY-Ahx-YGRKKRRQRRR-NH2) 2mg　217593

特徴

• A 13-mer NMDA receptor 2B (NR2B) subunit carboxy terminal (1292-1304) derived peptide that specifically binds DAPK1 (death-associated protein kinase 1) in a reversible manner and antagonizes the activated DAPK1-NR2B interaction and the potentiation of nMDAR function with no effect on either the catalytic activity of DAPK1 or the nMDA receptor physiology. Blocks Ca2+ influx through extrasynaptic nMDA receptors (at 50uM) and the blood-brain-barrier permeable version, namely NR2BCT(1292-1304) attached to TAT(47-57) via a spacer (6-aminohexanoic acid) protects cortical neurons from nMDA receptor-mediated insults and reduces brain infarction and improve neurological functions in mice (10mg/kg, i.v.).
• Sequence:H2N-Lys-Lys-Asn-Arg-Asn-Lys-Leu-Arg-Arg-Gln-His-Ser-Tyr-Ahx-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-CONH2
• Molecular Formula:C₁₄₃H₂₅₄N₆₄O₃₂
• Molecular Weight:3382
• Solubility:DMSO (50mg/ml)
• Storage and Stability:Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.