A non-competitive, potent antagonist highly selective for mGlu5 receptors (IC50 = 5nM). Biologically active admitted orally or systematically. Widely used in assessing the functional roles of mGlu5 receptors in a variety of research areas, such as neuroprotection, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson's disease.
Formula:C11H8N2SHCl
Primary Target:mGlu5 receptors
Primary Target IC50:5nM
Solubility:H2O
Storage and Stability:May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.