85-2074-52　Mitochondrial Pyruvate Carrier Inhibitor, UK5099 ((E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)acrylic acid, (E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid, MPC Inhibitor, PF-1005023) 5mg　CAS No:56396-35-1　217555

特徴

• A cell-permeable alpha-cyanocinnamate compound that acts as a rapid, active site thiol modifying, time-dependent and non-competitive inhibitor of bi-directional pyruvate transport across plasma membranes in yeast, bacteria, Drosophila, and humans (IC50 = 50nM in rat heart mitochondria; Ki ≤1uM) with excellent selectivity over monocarboxylates and anions. Shown to significantly decrease pyruvate-driven respiration, enhance glucose uptake and activate AMPK (2uM in human myocytes and skeletal muscle myotubes).
• Molecular Formula:C₁₈H₁₂N₂O₂
• Solubility:DMSO
• Primary Target:mitochondria
• Storage and Stability:May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

仕様

• Size：5mg
• Grade：Highly Purified
• Purity：≥99% (HPLC)
• Form：Supplied as a bright yellow solid.
• EU Commodity Code：38220090
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• 製品の仕様は予告なく変更になる場合がございます。最新仕様はメーカーホームページをご確認ください。
• CAS No ：56396-35-1

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