A cell-permeable morpholino-benzodioxol compound that inhibits MIF tautomerase activity (Ki and IC50 = 0.57 and 2.4uM, respectively) via direct non-covalent MIF interaction ( = 24.5uM). RDR 03758 at 10uM is shown to completely neutralize the overriding effect of 100ng/ml MIF on the inhibition of LPS-stimulated TNF production by dexamethasone in RAW 264.7 marcophage cultures.
Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
