85-2074-23　LSF Inhibitor, FQI1 ((±, 8-(2-Ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6(5H)-one Factor Quinolinone Inhibitor 1, Racemic) 10mg　217522

特徴

• A cell-permeable dihydroquinolinone compound that acts as a potent, specific, and reversible inhibitor of DNA-binding activity of Late SV40 Factor (LSF) and blocks LSF transactivation (IC50=2.1uM in NIH 3T3 cells). Exhibits anti-proliferative activity and growth arrest in multiple cell lines (GI50=3.8, 0.79, and 6.3uM in NIH 3T3, HeLa S3 and A549 cells, respectively). Shown to induce apoptotic cell death in liver cancer cell lines over-expressing LSF without affecting primary or immortalized hepatocytes. Also shown to inhibit hepatocellular carcinoma s.c. growth in mouse xenograft model without any toxic effects (1mg/kg, i.p., once every 3 days).
• Formula:C18H17NO4
• Molecular Weight:311.3
• Solubility:DMSO (100mg/ml)
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.