85-2074-15　LIM Kinase Inhibitor I, LIMKi 3 (N-(5-(1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyramide) 10mg　217513

特徴

• A cell-permeable pyrazolylthiazolo-isobutyramide compound that acts as a potent LIM kinase inhibitor (IC50 = 7 and 8nM against LIMK1 and LIMK2, respectively) and effectively suppresses cellular cofilin phosphorylation (IC50 ~1uM in A549 and MDA-MB-231 cultures) without affecting tubulin polymerization or inducing cytotoxicity (EC50 >10uM in A549 proliferation & colony formation assays). Shown to effectively destabilize F-actin structure in MDA-MB-231 breast cancer cells (3 to 10uM) with concomitant blockage of invasion (by 93% at 10uM).
• Molecular Formula:C₁₇H₁₄Cl₂F₂N₄OS
• Solubility:DMSO
• Primary Target:LIMK1 and LIMK2
• Primary Target IC50:7 and 8nM against LIMK1 and LIMK2, respectively
• Secondary Target:AMPKA1, AMPKA2, DDR1, PAK3, DCAMKL2
• Molar Mass:431.3
• Purity:≥95% (HPLC)
• Form:Supplied as a beige powder.
• Storage and Stability:Store at 4°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.