A furanyl thiazolidinone compound that binds CD11b aA/aI domain in a reversible manner and stabilizes aA in a high-affinity binding conformation toward known CD11b/CD18 (aMB2; CR3; Mac-1) ligands, fibrinogen, ICAM-1, and iC3B. Reported to be superior to IMB-10 in enhancing Mac-1-mediated cell adhesion (EC50=4 vs. >50uM on fibrinogen surface). Effectively suppresses leukocyte recruitment in various inflammatory disease models involving mice, rats, and zebrafish embryos in vivo.
Formula:C₂₂H₁₅NO₄S₂
Molecular Weight:421.5
Solubility:DMSO
Storage and Stability:Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
