Selective D4 receptor antagonist with excellent brain penetration. Displays an affinity (Ki) of 0.4nM for human D4 receptors with >1000-fold binding selectivity over D2 and D3 receptors. Does not block agonist-induced activation of GIRK currents. It is used frequently in retinal and CNS studies of D4 modulation.
Formula:C₁₈H₁₉N₄Cl•3HCl
Solubility:H2O
Primary Target:D4
Primary Target Ki:0.4nM
Purity:≥99% (HPLC)
Form:Supplied as an off-white solid.
Storage and Stability:May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
