85-2074-02　KMO Inhibitor I, Ro 61-8048 (Kynurenine-3-Monooxygenase Inhibitor I, Ro 61-8048 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide Dimethoxy-nitrophenyl-thiazolyl-benzenesulfonamide, Kynurenine-3-Hydroxylase Inhibitor I, Ro 61-8048) 10mg　217494

特徴

• A cell-permeable thiazolylbenzenesulfonamide compound that acts as a potent, competitive and reversible inhibitor of kynurenine-3-monooxygenase activity (Ki=4.8nM; IC50=37nM). Reported to increase the circulating levels of kynurenic acid (KYNA), an excitatory amino acid receptors antagonist, lower reactive oxygen species [ROS], reduce neuronal loss and enhance the survival rate in several neuronal disease models. An orally bioavilable KMO Inhibitor II, JM6, a prodrug of Ro 61-8048 is also available.
• Molecular Formula:C₁₇H₁₅N₃O₆S₂
• Molecular Weight:421.5
• Solubility:DMSO (100mg/ml)
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

仕様

• Size：10mg
• Grade：Highly Purified
• Purity：≥99% (HPLC)
• Form：Supplied as a yellow solid.
• Molecular Formula：C₁₇H₁₅N₃O₆S₂
• Molecular Weight Non Ab：421.5
• EU Commodity Code：38220090
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