An extremely potent, non-competitive antagonist for mGlu receptor subtype 1 (Ki = 0.34nM; IC50 = 0.55nM). 400-fold more selective for mGlu1 than for mGlu5 and no interaction with mGlu2, mGlu3, mGlu4, mGlu6, AMPA ornMDA receptors (IC50 >10uM). Centrally active following systemic administration. Widely used for studying substance abuse, learning and memory, and neural plasticity.
Storage and Stability:May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
