A nonpeptidic thiophenylmethanamine compound that binds interferon-a (Kd= 4uM for human IFN-a) and prevents IFN-a and IFNAR interaction-dependent IFN-a production in murine BM-pDCs (bone marrow-derived plasmacytoid dendritic cells) cultures upon MVA infection (IC50<4.5uM), while exhibiting no inhibitory effect against IL-12 production in the same cultures when applied at non-toxic concentrations (<4.5uM).
Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
