A partial non-competitive antagonist highly selective for GluN1/N2B subtype nMDA receptors (IC50 = 0.15uM, maximal inhibition ˜90%) over other subtypes (IC50 = 39, 29, 76uM for GluN1/N2A, GluN1/N2C and GluN1/N2D subtype receptors, respectively). Frequently used in studies of various brain functions and disorders involving neural transmissions mediated by GluN1/N2B subtype nMDA receptors.
Formula:C21H27NO2•0.5C4H6O6
Primary Target:GluN1/N2B subtypenMDA receptors
Primary Target IC50:0.15 →M
Solubility:DMSO
Storage and Stability:May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
