A potent negative allosteric modulator selective for AMPA glutamate receptors (IC50 = 10-20uM) over kainate (IC50 ~450uM) and nMDA (IC50 >> 50uM) receptors. Commonly used as neuroprotectant, anticonvulsant, and skeletal muscle relaxant. Biologically viable admitted orally or systematically.
Formula:C17H15N3O2•HCl
Primary Target:AMPA
Primary Target IC50:10-20 →M
Molar Mass:329.78
Solubility:H2O
Storage and Stability:May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
